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. 2021 Dec 7;22(24):13190. doi: 10.3390/ijms222413190

Table 6.

Mycostatic selectivity in relation to mammalian cell lines.

Compound IC50 HEK293/MIC90
Candida albicans
ATCC 10231
Candida glabrata
ATCC 90030
Candida krusei
ATCC 6258
Candida parapsilosis
ATCC 22019
Saccharomyces cerevisiae
ATCC 9763
R8 - - - - -
C-1311 <0.00005 <0.00005 <0.00005 <0.00005 <0.00005
Compound 1 <0.0058 <0.0058 <0.0058 <0.0058 <0.0058
Compound 1-R8 2.22 0.56 4.44 8.88 2.22
IC50 HEPG2/MIC90
R8 - - - - -
C-1311 <0.00078 <0.00078 <0.00078 <0.00078 <0.00078
Compound 1 <0.0038 <0.0038 <0.0038 <0.0038 <0.0038
Compound 1-R8 1.58 0.40 3.17 6.33 1.58