Table 6.
Mycostatic selectivity in relation to mammalian cell lines.
Compound | IC50 HEK293/MIC90 | ||||
---|---|---|---|---|---|
Candida albicans ATCC 10231 |
Candida glabrata ATCC 90030 |
Candida krusei ATCC 6258 |
Candida parapsilosis ATCC 22019 |
Saccharomyces cerevisiae ATCC 9763 |
|
R8 | - | - | - | - | - |
C-1311 | <0.00005 | <0.00005 | <0.00005 | <0.00005 | <0.00005 |
Compound 1 | <0.0058 | <0.0058 | <0.0058 | <0.0058 | <0.0058 |
Compound 1-R8 | 2.22 | 0.56 | 4.44 | 8.88 | 2.22 |
IC50 HEPG2/MIC90 | |||||
R8 | - | - | - | - | - |
C-1311 | <0.00078 | <0.00078 | <0.00078 | <0.00078 | <0.00078 |
Compound 1 | <0.0038 | <0.0038 | <0.0038 | <0.0038 | <0.0038 |
Compound 1-R8 | 1.58 | 0.40 | 3.17 | 6.33 | 1.58 |