Table 2.

T regs display both pro and anti-inflammatory responses in CTI during initial phases/immediately after trauma.

T regs in CTI	Functional Consequences
Increase in Tregs number and activity immediately after CTI	Undesirable suppression of pro-inflammatory Th-1 type cytokines delaying wound healing
Early phase increased expression of IL-10	Suppression of pro-inflammatory responses (Th1 type and IFN-γ delaying wound healing
Presence of TGF-β and IL-6 convert Tregs to TH17 cells	Increase unrequired inflammatory responses
T regs suppress DC maturation	Inducing anergy in T cells
T regs loose regulatory function on neutrophils, and conventional T cell functions	Loss of transition of inflammatory phase to regenerative and repair phase
Absence of Tregs	Myogenic activity
Expression of amphiregulin by Tregs	Controls muscle-homeostatis
Loss of IL-33 in stimulated Tregs	Impaired tissue repair