Table 1.

Current pharmaceutical agents for the treatment of senescence and their associated adverse effects with chronic, long-term use.

Pharmaceutical Agent	Mechanism	Long-Term Side Effects
Dasatinib + Quercetin	Senolytic	Currently unknown with further investigation required [129].
Navitoclax	Senolytic	Platelet toxicity or thrombocytopenia [130,131]; neutrophil toxicity [132].
Rapamycin	Senostatic	Glucose intolerance; insulin resistance; hyperglycemia; starvation pseudo-diabetes; stomatitis; mucositis; interstitial pneumonitis [133].
Metformin	Senostatic	Shortened lifespan; mitochondrial dysfunction; lethal ATP exhaustion [134,135].

ATP = adenoside triphosphate.