Table 2.
The role of SASP in various skin indications and evidence of probiotic impact.
Skin Disease | SASP Factor(s) Involved | Probiotic Influence on Factor(s) and Disease |
---|---|---|
Aging | Upregulated: |
|
Carcinogenesis | Upregulated: |
|
Dyspigmentation | Modulated: |
|
Psoriasis and Atopic Dermatitis | Upregulated: |
|
Acne Vulgaris | Upregulated: | |
Chronic Wounds | Upregulated: |
|
Immunity Decline | Dysregulated: |
|
MMP = matrix metalloproteinase; TNF-α = tumor necrosis factor-alpha; IL = interleukin; UV = ultraviolet; MAPK = mitogen-activated protein kinases; p16INK4a = cyclin-dependent kinase inhibitor 2A; HGF = hepatocyte growth factor; CXCL = chemokine ligand; CD = cluster of differentiation; IFN-γ = interferon gamma.