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Action of Betulin (B) and Betulinic Acid (BA) on cyclooxygenase enzymes (Cox-1 and Cox-2) which convert the arachidonic acid to prostaglandins. Inhibition of prostaglandin PGE2 derived from Cox-2 by blocking its pathway through Betulin (B) and Betulinic Acid (BA) leads to inhibition of angiogenesis, proliferative invasion.
