Figure 5.

Co-treatment with WSG and cisplatin suppresses tumorigenesis in the lung tissues of mice injected with LLC1 cells. (A) Experimental schematic. LLC1 cells were injected through the lateral tail veins of the mice (n = 5). The LLC1-bearing mice were intraperitoneally injected with cisplatin and WSG. (B) At the end of the treatment, lung tissue was collected. One of five tissue samples is presented. As indicated by the blue arrows, tumor lesions were observed on the surface of the lung tissues. Lower panels of the lung sections under H&E staining (20× magnification). Bar scale: 2 mm. (C) Tumors (nodules) in the lung lesions. (D) Tumor volume (mm³) of the lung lesions. Each bar represents the mean ± standard deviation. Significant differences between the treatment and control groups are presented (* p < 0.05, ** p < 0.01, *** p < 0.001). (E) Combination treatment increased the survival rate of LLC1-bearing mice (n = 8).