Table 1.
List of some recently completed or terminated clinical trials that evaluated aPDT to treat diverse infectious diseases.
| Medical Conditions | Target Micro-Organism(s) | Photosensitizer | Trial Phase | Number and Year |
|---|---|---|---|---|
| Acne | Propionibacterium acnes | Butenyl ALA | N.A. | NCT02313467, 2014 |
| Lemuteporfin | Phase 1/2 | NCT01490736, 2011 | ||
| 5-ALA | Phase 2 | NCT01689935, 2012 | ||
| Methyl aminolevulinate | Phase 2 | NCT00673933, 2013 | ||
| Dental caries | Streptococcus mutans, Streptococcus sobrinus, Lactobacillus casei, Fusobacterium nucleatum, and Atopobium rimae | TBO | Phase 1 | NCT02479958, 2015 |
| MB | Phase 1 | NCT02479958, 2015 | ||
| Aggregatibacter actinomycetemcomitans, Tannerella forsythia and Porphyromonas gingivalis | N.C. | N.A. | NCT03309748, 2017 | |
| Denture-related stomatitis | Candida albicans | MB | Phase 4 | NCT02642900, 2015 |
| Orthodontic | N.D. | Curcumin | Phase 1 | NCT02337192, 2015 |
| Peri-implantitis | N.D. | N.D. | Phase 3 | NCT02848482, 2016 |
| Periodontic | Aggregatibacter Actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Treponema denticola | MB | N.A. | NCT03750162, 2018 |
| ICG | Phase 2 | NCT02043340, 2014 | ||
| Methyl aminolevulinate | Phase 2 | NCT00933543, 2013 | ||
| MB | N.A. | NCT03262077, 2017 | ||
| MB | Phase 2 | NCT03074136, 2017 | ||
| Phenothiazine hydrochloride | Phase 4 | NCT03498404, 2018 | ||
| TB | Phase 4 | NCT03412331, 2018 | ||
| Distal subungual onychomycosis | Fungi infecting nails | 5-ALA | Phase 2 | NCT02355899, 2015 |
| Endodontic | E. faecalis and C. albicans | MB | Phase 2 | NCT02824601, 2016 |
| HPV infection | Human Papillomavirus (HPV) | 5-ALA | Phase 2 | NCT02631863, 2015 |
| Leg ulcers | Streptococci, anaerobes, coliform, S. aureus, P. aeruginosa, yeast, and diphtheroids | PPA904 | Phase 2 | NCT00825760, 2009 |
Studies collected from ClinicalTrials.gov (https://clinicaltrials.gov/ct2/results?cond=photodynamic+therapy, Accessed Date: 1 March 2021). ALA, alanine; MB, methylene blue; N.A., not applicable; N.C., not communicated; N.D., not determined; PPA904, 3,7-bis(di-n-butylamino)phenothiazin-5-ium bromide; and TB (or TBO), toluidine blue.