Table 2.
Factors associated with viral suppression in a cohort of Mexican persons living with HIV, 2017–2019.
| Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|
| Characteristics | OR; IC95% | p-Value | OR; IC95% | p-Value | OR; IC95% | p-Value |
| Group | ||||||
| Naïve + non-resistant | 1 | 1 | 1 | |||
| Naïve + resistant | 0.74; 0.50–1.09 | 0.14 | 0.79; 0.53–1.17 | 0.25 | 0.71; 0.47–1.07 | 0.10 |
| Experienced + non-resistant | 0.46; 0.32–0.66 | <0.001 | 0.49; 0.34–0.70 | <0.001 | 0.37; 0.24–0.53 | <0.001 |
| Experienced + resistant | 0.28; 0.09–0.87 | 0.02 | 0.39; 0.13–1.15 | 0.09 | 0.26; 0.08–0.83 | 0.02 |
| CD4+ T cell count at the time of HIV drug resistance test (cells/mm3) | 0.16 | 0.27 | 0.04 | |||
| 100 | 1 | 1 | 1 | |||
| 200 300 400 |
1.04; 0.89–1.21 1.03; 0.82–1.31 0.98; 0.77–1.25 |
1.04; 0.90–1.21 1.05; 0.84–1.32 1.00; 0.78–1.28 |
0.99; 0.85–1.16 0.95; 0.74–1.22 0.88; 0.67–1.14 |
|||
| Age at the time of HIV drug resistance test (years) 1 | 0.17 | 0.77 | ||||
| 30 | 1 | 1 | 1 | 0.03 | ||
| 40 | 1.25; 0.89–1.48 | 1.09; 0.97–1.24 | 1.10; 0.84–1.44 | |||
| 50 | 1.45; 1.04–2.04 | 1.29; 0.93–1.79 | 1.52; 1.05–2.19 | |||
| Transmission Risk | ||||||
| MSM | 1 | 1 | 1 | |||
| Heterosexual cisgender men | 0.77: 0.56–1.06 | 0.11 | 0.80; 0.58–1.07 | 0.13 | 0.75; 0.54–1.05 | 0.09 |
| Heterosexual cisgender women | 0.74; 0.53–1.03 | 0.82 | 0.73; 0.53–1.00 | 0.69 | 0.76; 0.53–1.08 | 0.97 |
| Education level | 0.56 | 0.73 | ||||
| Elementary or lower | 0.90; 0.64–1.27 | 0.94; 0.68–0.30 | 0.89; 0.62–1.28 | 0.55 | ||
| High school or higher | 1 | 1 | 1 | |||
| Employment status | 0.73 | 0.99 | ||||
| Unemployed | 0.96; 0.75–1.22 | 1.00; 0.79–1.27 | 0.76; 0.59–0.99 | 0.004 | ||
| Employed | 1 | 1 | 1 | |||
| Change in ART regimen | NA | NA | NA | NA | 1.78; 1.15–2.75 | 0.009 |
Model 1 was fitted by sex, antiretroviral treatment + exposure drug resistance group, CD4+ T cell count, age, transmission risk, education level and employment status, n = 1454; Model 2 includes the same variables of Model 1 using imputation of missing data to improve dataset completeness, n = 1780; and Model 3 includes the variable change in the ART regimen, n = 1445. 1 Age was modelled using splines with 3 nodes, the reference age selected for the results was 30 years old. MSM: Men who have sex with men, NA: not available.