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. 2021 Dec 17;14(12):1322. doi: 10.3390/ph14121322

Figure 3.

Figure 3

The eNAMPT-neutralizing mAb, ALT-100, prevents PCa invasion and metastasis. (A): DU145 xenograft invaded prostate glands (pros) and capsule in vehicle IgG-treated mice (left panel), and lymphovascular invasion (arrows, middle panel) was easily identified in DU145 xenografts in vehicle IgG-treated mice. In mAb-treated mice (right panel), DU145 xenografts appeared to push prostate glands (pro) without infiltration and lymphovascular invasion. (B): Percentage of mice with organ invasion and metastasis in vehicle-treated and mAb-treated DU145 orthotopic xenografts. No distant metastasis was observed in mAb-treated group. (C): PC3 xenograft extensively invaded prostate glands (pros) (left panel) and locally spread and directly invaded into pelvic skeletal muscle (middle panel). In mAb-treated mice (right panel), PC3 grew with a defined border without extensive invasion into the capsule and prostate glands (pros). (D): Percentage of mice with organ invasion and metastasis in vehicle-treated and mAb-treated PC3 orthotopic xenografts. Lower metastasis percentages were observed in mAb-treated group compared to vehicle-treated group. (A,C), H&E 200×.