TABLE 4.
Subgroup analysis for the effects of probiotics on CRP.
| Subgroup | No. of trials | No. of participants | I 2 (%) | Pooled SMD [95% CI] |
|---|---|---|---|---|
| Probiotics dose | ||||
| ≥ 1010 CFU/day | 3 | 206 | 74.4 | −0.25 [−0.82, 0.31] |
| < 1010 CFU/day | 6 | 295 | 0 | −0.11 [−0.34, 0.12] |
| NR | 3 | 115 | 52.9 | −0.45 [−1.00, 0.10] |
| Probiotics strain | ||||
| Single | 6 | 276 | 0 | −0.07 [−0.31, 0.17] |
| Multiple | 5 | 300 | 50.9 | −0.25 [−0.58, 0.09] |
| NR | 1 | 40 | 0 | -1.02 [-1.68, −0.35] |
| Duration of intervention | ||||
| ≤8 weeks | 5 | 212 | 22.9 | −0.36 [−0.67, −0.05] |
| >8 weeks | 7 | 404 | 38.8 | −0.13 [−0.38, 0.13] |
| Method of administration | ||||
| Powder/capsule | 6 | 329 | 40.2 | −0.19 [−0.48, 0.10] |
| Food | 6 | 287 | 41.8 | −0.25 [−0.56, 0.06] |