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. 2021 Nov 30;9(12):2481. doi: 10.3390/microorganisms9122481

Figure 1.

Figure 1

Schematic representation of single stranded SARS-CoV-2 genome structure with ∼30 kb nucleotides in length with a 5′cap structure and a 3′-poly(A) tail. The first ORF contains a frameshift in between a-1 of ORF1a and ORF1b which directly translated two polypeptides (pp1a and pp1ab). These polyproteins are processed by one or two papain-like proteases (PLpro) in which the dark blue upside-down triangle sign indicated the cleavage sites of 3CLpro, and by the 3C-like protease (3CLpro) in which the light blue upside-down triangle indicated the cleavage sites of 3CLpro, into the 16 nsps (nsp1–16).