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. 2021 Dec 4;11(12):838. doi: 10.3390/metabo11120838

Figure 1.

Figure 1

Figure 1

Modulation of gene expression adaptation during an obesogenic diet following transgenerational intake of EPA. (a) Venn diagram illustrating the genes differentially expressed in each comparison (significantly identified mRNA with p < 0.05 after FDR correction for multiple testing). (b) PLS-DA plot of mRNA expression levels of significantly regulated transcripts (p < 0.05 after correction for multiple testing). (c) Venn diagram illustrating the genes differentially expressed in each comparison (significantly identified mRNA with p < 0.05 before FDR correction for multiple testing). HFoleic (or HFo), mice from oleic/control lineage fed with the obesogenic diet; HFepa (or HFe), mice from EPA/omega 3 lineage fed with the obesogenic diet; Reference (or ref), mice from oleic/control lineage fed with the normocaloric diet.