Figure 5.

Morphology and epigenetic state of primary B cells infected with EBV. The EBV genome in virions is devoid of nucleosome structure and CpG DNA methylation, but is modified by histones and CpG methylation in infected cells. The host cell morphology and genome are significantly influenced by EBV infection. The red line indicates latent viral genome. Dark gray shadows in nuclei indicate strong heterochromatinization. Green, orange, and blue circles represent viral lytic gene products, and white circles represent viral latent gene products.