Table 1.
Subgroup placement of tested Drosophila SLC22 transporters, human orthologs, and fly tissue expression. Specific Drosophila SLC22 transporters were deemed orthologous to human counterparts based on DIOPT 9.0 and FlyBase classification [45]. Associated metabolites were assigned based on human or mammalian SLC22 functional data. Check mark indicates expression in that tissue. (L) denotes expression level of <1FPKM. n/a: not applicable. (*) listed on A14 denotes orphan transporter status, having no confirmed substrates.
| Related SLC22 Human Subgroups | SLC22 Subgroup Members | Drosophila SLC22 | SLC22 Human Ortholog | Likely Transported Antioxidants (Mammals) | Drosophila Tissue Expression | ||
|---|---|---|---|---|---|---|---|
| Gut | Fat Body | Malpighian Tubule | |||||
| OCTN/OCTN-related | A4, A5, A15, A16, A21 | CG6126 | A16 | Carnitine, carnitine derivatives, and EGT | ✓ | ✓ | ✓ |
| OATS2 | A7 | CG16727 | A7 | Uric acid | n/a | n/a | ✓ |
| OCT | A1, A2, A3 | CG6006 | A1, A2, A3 | Carnitine derivatives | ✓ | ✓ | ✓(L) |
| OATS1 | A6, A8, A20 | A6, A8 | Uric acid | ||||
| OATS2 | A7 | A7 | Uric acid | ||||
| OATS3 | A11, A12, A22 | A11, A12 | Uric acid | ||||
| OAT-like | A13, A14 | A13, A14 * | Uric acid | ||||
| OCT | A1, A2, A3 | CG4630 | A3 | Carnitine derivatives | ✓ | ✓(L) | ✓ |