Table 2.
Well-documented cutaneous manifestations of GH excess and deficiency in human skin. First listed is growth hormone (GH) excess, leading to acromegaly or gigantism, as seen in somatotroph adenoma of the anterior pituitary, neurofibromatosis-1, McCune Albright syndrome, multiple endocrine neoplasia type 1, Carney complex, and others. Then listed is growth hormone deficiency, as seen in Noonan syndrome, Turner syndrome, Prader–Willi Syndrome, and Laron syndrome, referenced from Kanaka-Gantenbein et al., 2016.
| Condition | Cutaneous Manifestation | Reference |
|---|---|---|
| GH excess | Hypertrichosis | [35] |
| Hirsutism | ||
| Cutis verticis gyrata | ||
| Acrochordons | ||
| Lentiginous spots | ||
| Melanocytic nevi | ||
| Acanthosis nigricans | ||
| Acne | ||
| Seborrhea | ||
| Hyperidrosis | ||
| GH deficiency | Alopecia | [35,36] |
| Frontal hairline recession | ||
| Telogen effluvium | ||
| Dryness | ||
| Thinner dermis | ||
| Hypopigmentation | ||
| Hypohidrosis | ||
| SST Therapy | Reversible scalp hair loss | [37,38,39,40] |
| Low IGF-1 levels | Hair loss | [41] |
| GHRH deficiency | No hair loss; delayed pigmentation | [42] |