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. 2021 Dec 10;11(12):1347. doi: 10.3390/jpm11121347

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Representation of SD and EID groups in some CD4⁺ and CD8⁺ T lymphocytes, and CD19⁺ B lymphocytes subpopulations in RRMS patients under Natalizumab treatment in both first (V1) and second (V2) extractions. Percentage of expression of CD49d in (a) CD8⁺CD27⁺ T lymphocytes and (b) CD19⁺ DN B lymphocytes. Each dot represents the percentage of expression for each marker regarding their parent population (CD4⁺ or CD8⁺ T lymphocytes, or CD19⁺ B lymphocytes populations) in the SD (n = 8) or EID (n = 21) groups. DN, Double Negative; EID, extended interval dosing; NTZ, natalizumab; SD, standard dosing. Ns: p > 0.05, * p < 0.05, ** p < 0.01.