Figure A4.

Representation of SD and EID groups in some CD4⁺ and CD8⁺ T lymphocytes subpopulations in RRMS patients under Natalizumab treatment in both first (V1) and second (V2) extractions. Percentage of expression of CD49d in (a) CD4⁺CD27⁺, (b) CD4⁺ Effector Memory (EM), (c) CD8⁺ Effector and (d) CD8⁺ Effector Memory (EM) T lymphocytes Each dot represents the percentage of expression for each marker regarding their parent population (CD4⁺ or CD8⁺ T lymphocytes populations) in the SD (n = 8) or EID (n = 21) groups. EID, extended interval dosing; EM, effector memory; SD, standard dosing. ns: p > 0.05, * p < 0.05.