Table 1.
Examples of drugs and associated genes with actionable prescribing recommendations from the Clinical Pharmacogenetics Implementation Consortium guidelines and/or U.S. Food and Drug Administration-approved drug labeling.
| Medications | Genes |
|---|---|
| Cardiology | |
| Clopidogrel | CYP2C19 |
| Simvastatin | SLCO1B1 |
| Warfarin | CYP2C9, CYP4F2, VKORC1 |
| Gastroenterology | |
| Dexlansoprazole | CYP2C19 |
| Lansoprazole | CYP2C19 |
| Metoclopramide | CYP2D6 |
| Omeprazole | CYP2C19 |
| Ondansetron | CYP2D6 |
| Pantoprazole | CYP2C19 |
| Immunosuppressants | |
| Azathioprine | NUDT15, TPMT |
| Mercaptopurine | NUDT15, TPMT |
| Tacrolimus | CYP3A5 |
| Infectious Disease | |
| Abacavir | HLA-B |
| Atazanavir | UGT1A1 |
| Efavirenz | CYP2B6 |
| Voriconazole | CYP2C19 |
| Neurology | |
| Carbamazepine | HLA-A, HLA-B |
| Oxcarbazepine | HLA-B |
| Phenytoin | CYP2C9, HLA-B |
| Pain Management | |
| Celecoxib | CYP2C9 |
| Codeine | CYP2D6 |
| Flurbiprofen | CYP2C9 |
| Hydrocodone | CYP2D6 |
| Ibuprofen | CYP2C9 |
| Meloxicam | CYP2C9 |
| Piroxicam | CYP2C9 |
| Tramadol | CYP2D6 |
| Psychiatry | |
| Amitriptyline | CYP2D6, CYP2C19 |
| Aripiprazole | CYP2D6 |
| Atomoxetine | CYP2D6 |
| Brexpiprazole | CYP2D6 |
| Citalopram | CYP2C19 |
| Clobazam | CYP2C19 |
| Clomipramine | CYP2D6, CYP2C19 |
| Desipramine | CYP2D6 |
| Doxepin | CYP2D6, CYP2C19 |
| Escitalopram | CYP2C19 |
| Fluvoxamine | CYP2D6 |
| Imipramine | CYP2D6, CYP2C19 |
| Nortriptyline | CYP2D6 |
| Paroxetine | CYP2D6 |
| Pimozide | CYP2D6 |
| Sertraline | CYP2C19 |
| Trimipramine | CYP2D6, CYP2C19 |
| Vortioxetine | CYP2D6 |
| Urate-Lowering Therapy | |
| Allopurinol | HLA-B |
| Rasburicase | G6PD |