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. 2021 Nov 30;13(12):2400. doi: 10.3390/v13122400

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Pro-inflammatory cytokines in monocytes from SLGN-treated individuals. Pseudo color flow plots show gating strategy for measuring ex vivo expression of pro-inflammatory cytokines (A) IL-6 and (B) IL-18 in CD14⁺ monocytes. Frequencies of cytokine producing monocytes from baseline and 8-h samples in placebo, 1.5 or 3.0 mg SLGN-treated individuals are presented for (C) IL-6 and (D) IL-18, respectively. Significance was calculated by a Wilcoxon matched-pairs signed-rank test, and p value ≤ 0.05 * and 0.001 *** show grades of significance. ns: no significance.