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. 2021 Dec 19;13(12):2196. doi: 10.3390/pharmaceutics13122196

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Results of in vitro and ex vivo syringeability assays of the combination products, performed in triplicate measurements at ambient temperature. (A1) Comparative mean injection forces required to extrude the product formulas through the specified administration system. The individual values were obtained over a distance of 1 mm in the linear phase of the force injection profile, and the mean recorded forces were assorted with the corresponding standard deviations as the error bars. (A2) Comparative force injection profiles of the product formulas with injection into air. (B1) Comparative mean injection forces required to extrude the product formulas through the specified administration system into an ex vivo equine tendon tissue sample. The individual recorded values were obtained over a period of 1 s at half distance on the force injection profile, and the mean recorded forces were assorted with the corresponding standard deviations as the error bars. (B2) Comparative force injection profiles of the product formulas with injection into an ex vivo equine tendon tissue sample. HA, hyaluronic acid; N, Newtons.