Table 1.

Parameter values and initial conditions.

Parameter	Description	Sample Value	Units	Reference
r	Net virus growth rate	0.58	day ${}^{-1}$	[19,23]
$\mu$	Mutation rate	$4.655\times {10}^{-5}$	–	[23,27]
$K_1$	WT carrying capacity	$2.000\times {10}^6$	virus/mL	Fitted
p	Antibody-neutralisation rate of WT	0.0142	mL/(mg·day)	[23]
c	Fitness cost of mutant	0.19	–	[19]
$K_2$	Mutant carrying capacity	$4.732\times {10}^3$	virus/mL	Fitted
q	Ab neutralisation rate of mutant	0.19	–	Variable
d	Antibody decay rate	0.0315	day ${}^{-1}$	[23]
$A_{\inf }$	Antibody infusion	38.4	mg/mL	[11,12,23]
$\tau$	Period	7	days	Variable
k	Number of infusions	3	–	Variable
$t_k$	time of the kth infusion	7	days	[11,12]
$W\left(0\right)$	Initial wild-type levels	224	virus/mL	[23]
$M\left(0\right)$	Initial mutant levels	9	virus/mL	[23]
$A\left(0\right)$	Initial antibody levels	37.2	mg/mL	[23]