Figure 3.

The effects of ent-cis-195A, cis-211A, and 6-epi-211A on α7- and α4β2-nicotinic acetylcholine receptors expressed in Xenopus oocytes. (A–F). Concentration–inhibition curves for ent-cis-195A (A,B), cis-211A (C,D), and 6-epi-211A (E,F) on α7- (A,C,E) and α4β2-nicotinic receptors (B,D,F). Current response to acetylcholine (ACh) in the presence of alkaloid was normalized to the current elicited by ACh alone in the same oocyte and averaged. Values represent the mean ± S.E.M. (A–D): n = 3–5, E: n = 3–4, F: n = 4–5.