Table 1.

Adverse effects of bivalent and quadrivalent HPV vaccines.

Adverse Effect	Vaccine Type	Relative Risk	95% CI
Overall adverse effects at the injection site [15]	Bivalent and quadrivalent	1.18	1.16 to 1.20
Overall systemic events [15]	Bivalent and quadrivalent	1.02	0.98 to 1.07
Serious adverse event [15]	Bivalent And quadrivalent	1.01	0.95 to 1.07
Autoimmune-related conditions [25]	Bivalent	0.98	0.80 to 1.21
Thromboembolic event [26]	Quadrivalent	0.7	0.3 to 1.4
Chronic fatigue syndrome [27]	Quadrivalent	0.94	0.78 to 1.14
Multiple sclerosis [28]	Quadrivalent	0.3	0.1 to 0.9
Connective disorders [28]	Quadrivalent	0.8	0.3 to 2.4
Type 1 diabetes [28]	Quadrivalent	1.2	0.4 to 3.6
Guillain–Barré syndrome (GBS) [29]	Bivalent and quadrivalent	3.78	1.79 to 7.98
	Bivalent	8.08	1.69 to 38.61
	Quadrivalent	3.78	1.70 to 8.41
Thyroiditis [30]	Bivalent	3.75	1.25 to 11.31
Inflammatory bowel disease [29]	Bivalent and quadrivalent	1.14	0.97 to 1.35
	Bivalent [31]	1.11	0.75 to 1.66