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CDK 4/6 mediated cell cycle progression. Under normal conditions, the phosphorylation of the retinoblastoma protein (Rb) by the CDK 4/6—cyclin D complex results in its dissociation from E2F thereby allowing for the transcription of genes for cell cycle progression. CDK4/6 inhibitors such as Palbociclib aim to prevent the progression of the cell cycle and maintain cell cycle arrest
