Table 1.

Comparison of characteristics of different beta-D-glucan test assays.

Test Assay	Availability	Producer	Method	Cut-Off Value	Overall Sensitivity	Overall Specificity	Comments	Reference
Fungitell	Europe, US	Associates of Cape Cod, Falmouth, MA, USA	Colorimetric	Intermediate 60–79 pg/mL Positive > 80 pg/mL	27–100%	0–100%	BDG detection by Fungitell is part of EORTC/MSG criteria (positive serum BDG in combination with host factor and clinical criterion) for probable invasive candidiasis or PJP.	[7,8,9]
Fungitell STAT	Europe, US	Associates of Cape Cod, Falmouth, MA, USA		Indeterminate 0.75–1.1 Positive ≥ 1.2	ND	ND	New rapid test that can be run on one or more patient specimens (single sample testing), but initial clinical validation reported 98–99% concordance with indeterminate results excluded and 74–91% if included.	[11]
Glucatell	Europe, US	Associates of Cape Cod, Falmouth, MA, USA	Colorimetric	80 pg/mL	50–92%	41–94%	The Glucatell test differs from the Fungitell test in that the Glucatell reagent is processed to eliminate Factor C. This makes the Glucatell test more specific for BDG linkages. The Glucatell reagent does not react to other polysaccharides, including beta-glucans with other glycosidic linkages.	[7,9]
Wako Wako-EU	Asia, Europe	Wako Pure Chemical Industries, Osaka, Japan	Turbidimetric method	11 pg/mL	50–86%	89–100%		[7,8,9,10]
Fungitec G test ES Fungitec G test MKII	Europe, US	Seikagaku Kogyo Corporation, Tokyo, Japan Subsidiary Associates of Cape Cod, Falmouth, MA, USA	Colorimetric method	20 pg/mL	67–88%	60–85%		[7,9]
Dynamiker Fungus	Some European countries and North Africa	Dynamiker Biotechnology Ltd., Tianjin, China	Turbidimetric method	95 pg/mL	64–81%	78–80%		[7,9]

ND, no data.