Table 5.
Multivariate Cox regression analysis for overall survival and progression-free survival.
| Characteristic (Reference) | OS * | PFS ** | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | |
| Sex (male) | 4.121 | 1.11–15.27 | 0.034 | 1.379 | 0.45–4.20 | 0.571 |
| Age (≥30 years) | 2.023 | 0.64–6.44 | 0.233 | 1.817 | 0.67–4.96 | 0.244 |
| Histological subtype (NS) | ||||||
| MC | 0.112 | 0.01–1.07 | 0.057 | 0.147 | 0.02–1.39 | 0.093 |
| LR | 0.866 | 0.14–5.46 | 0.878 | 1.427 | 0.27–7.64 | 0.678 |
| NOS | 0.189 | 0.03–1.22 | 0.080 | 0.292 | 0.06–1.47 | 0.134 |
| Ann Arbor stage (IV) | ||||||
| I/II | 0.074 | 0.01–0.47 | 0.006 | 0.145 | 0.04–0.57 | 0.006 |
| III | 2.077 | 0.49–8.75 | 0.319 | 1.815 | 0.49–6.71 | 0.371 |
| B symptoms (absence) | 0.695 | 0.23–2.07 | 0.514 | 0.482 | 0.16–1.42 | 0.185 |
| Bulky disease (presence) | 0.102 | 0.02–0.48 | 0.004 | 0.289 | 0.08–1.06 | 0.062 |
| EBV-LMP1 (positive) | 0.605 | 0.20–1.82 | 0.370 | 0.754 | 0.27–2.09 | 0.588 |
* Model for OS: χ2 = 20.664; p = 0.024. ** Model for PFS: χ2 = 19.999; p = 0.029. NS, Nodular sclerosis; MC, Mixed cellularity; LR, Lymphocyte-rich; NOS, Not otherwise specified; EBV-LMP1, Epstein–Barr Virus Latent Membrane Protein 1; IPS, International Prognostic Score; GSHG, German Hodgkin Study Group, Cologne, Germany. Boldface font indicates statistical significance (p < 0.05).