Table 2.

The general structures of some of the most recent (published in 2021), successful synthetic efforts from academia.

Structural Type	General Structure *	Target	Ref.
Phloeodictine analogues		Fungal ergosterol biosynthesis	[59]
Biphenylethylaminoacetamides		Fungal cell wall integrity	[60]
Thiazoyl guanidine derivatives		Fungal ergosterol biosynthesis	[61]
Carboline HDAC inhibitors		Fungal histone deacetylase	[62]
Acyl hydrazides		Fungal fatty acid biosynthesis	[64]
Thiobenzoate scaffolds		Dual target: fungal acetohydroxyacid synthase and NLRP3 inflammasome	[65]

* Adapted with permission from refs. [59,60,61,62,64,65]. Copyright 2021 American Chemical Society.