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. 2021 Dec 12;22(24):13348. doi: 10.3390/ijms222413348

Figure 2.

Figure 2

Regulation of HLA-G gene expression considering the genetic polymorphism of the SNP type based on [17,29,31,32,33,34,35,36]. (A) The 5′ regulatory region of the HLA-G gene; and (B) the polymorphism of the 3′UTR region of the HLA-G gene. Abbreviations: ATF1: cyclic AMP-dependent transcription factor ATF-1; C-jun: transcription factor encoded by the JUN gene; CRE: cAMP response element; CREB1: CAMP responsive element binding protein 1; GAS: interferon-gamma activated site; gL: LINE-1 retrotransposon at the HLA-G promoter; HRE: hypoxia response element; HSE: heat shock element; HSF1: heat shock factor 1; IRF1: interferon regulatory factor 1; ISRE: interferon-stimulated response element; LCR: locus control region (candidate); p50: nuclear factor NF-κ-B p105 subunit; PRE: progesterone response element; RFX5: DNA-binding protein RFX5 (RFX family); RRE: Ras response element; RREB1: Ras responsive element binding protein 1; Sp1: transcription factor Sp1 (also known as specificity protein 1).