Table 3.
Selected examples of the influence of the HLA-G immunomodulating molecule on immune cells.
Name of Immune Cell | Tolerogenic Function of HLA-G | Reference |
---|---|---|
T cells | Inhibition of proliferation, cytolisys, and chemotaxis, cytotoxicity, and INF-y secretion | [67,68,69] |
Induction of Treg, cytokine produced by Th2 | [70] | |
B cells | Inhibition of proliferation, Ig secretion, and chemotaxis | [71,72] |
Neutrophils | Inhibition of phagocytosis and reactive oxygen species production | [73] |
Dendritic cells | Inhibition of maturation and NK cell activation | [54,74] |
Induction of anergic and suppressor T cells, and tolerogenic DC | [54,75,76] | |
NK cells | Inhibition of chemotaxis, cytotoxicity, and INF-y secretion | [77,78] |