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. 2021 Dec 12;22(24):13348. doi: 10.3390/ijms222413348

Table 3.

Selected examples of the influence of the HLA-G immunomodulating molecule on immune cells.

Name of Immune Cell Tolerogenic Function of HLA-G Reference
T cells Inhibition of proliferation, cytolisys, and chemotaxis, cytotoxicity, and INF-y secretion [67,68,69]
Induction of Treg, cytokine produced by Th2 [70]
B cells Inhibition of proliferation, Ig secretion, and chemotaxis [71,72]
Neutrophils Inhibition of phagocytosis and reactive oxygen species production [73]
Dendritic cells Inhibition of maturation and NK cell activation [54,74]
Induction of anergic and suppressor T cells, and tolerogenic DC [54,75,76]
NK cells Inhibition of chemotaxis, cytotoxicity, and INF-y secretion [77,78]