Table 4.
The results of multifactor dimensionality reduction analysis for epistatic interaction between analyzed variants in NOS genes.
| Model | Loci Combination | Testing Balanced Accuracy (%) |
Cross-Validation Consistency | p-Value |
|---|---|---|---|---|
| Asthma | ||||
| 2-locus | NOS2 (608) and NOS2 (C/T) | 62.3 | 8 | 0.025 * |
| 3-locus | NOS1, NOS2 (608) and NOS2 (C/T) | 58.4 | 6 | 0.201 |
| 4-locus | NOS1, NOS3, NOS2 (608) and NOS2 (C/T) | 53.7 | 10 | 0.640 |
| Increased FeNO | ||||
| 2-locus | NOS2 608 and NOS3 | 44.9 | 6 | 0.961 |
| 3-locus | NOS1, NOS2 608 and NOS3 | 51.1 | 8 | 0.763 |
| 4-locus | NOS1, NOS3, NOS2 (608) and NOS2 (C/T) | 55.7 | 10 | 0.476 |
* Indicates significance.