Table 2.
List of cytokines/chemokines present and quantified (by Image J) in the membrane antibody array (Human Cytokine Antibody Array 5) stained with CM. The intensity column shows the average of the values of the treated samples. The other parameters provide different measures of the differences between treated and control samples. # hits: number of parameters for which a given cytokine was found to be significantly different between control and treated samples.
| Cytokine | Intensity | p-Value | Differential Intensity | Relative Fold Change | log2 FC | # Hits |
|---|---|---|---|---|---|---|
| Angiogenin | 0.3199 | 0.0028 | −0.1331 | −0.2938 | −0.5019 | 5 |
| BDNF | 0.4531 | 0.4293 | −0.0297 | −0.0616 | −0.0917 | 1 |
| BLC (CXCL13) | 0.0715 | 0.1307 | −0.0895 | −0.5558 | −1.1708 | 0 |
| Ck beta 8-1 (CCL23) | 0.0322 | 0.1344 | −0.1055 | −0.7660 | −2.0955 | 0 |
| EGF | 0.0100 | 0.0904 | −0.1008 | −0.9097 | −3.4698 | 0 |
| ENA-78 (CXCL5) | 0.0464 | 0.1580 | −0.0459 | −0.4973 | −0.9922 | 0 |
| Eotaxin-1 (CCL11) | 0.0208 | 0.1268 | −0.0918 | −0.8155 | −2.4387 | 0 |
| Eotaxin-2 (CCL24) | 0.0100 | 0.1782 | −0.0778 | −0.8861 | −3.1341 | 0 |
| Eotaxin-3 (CCL26) | 0.0100 | 0.0456 | −0.0325 | −0.7647 | −2.0872 | 2 |
| FGF-4 | 0.1738 | 0.4402 | 0.0288 | 0.1987 | 0.2614 | 0 |
| FGF-6 | 0.1882 | 0.0561 | 0.0600 | 0.4679 | 0.5538 | 1 |
| FGF-7 (KGF) | 0.0997 | 0.1638 | 0.0436 | 0.7776 | 0.8300 | 4 |
| FGF-9 | 0.2474 | 0.5959 | 0.0315 | 0.1460 | 0.1966 | 1 |
| FLT-3 Ligand | 0.1239 | 0.5896 | −0.0123 | −0.0906 | −0.1370 | 0 |
| Fractalkine (CX3CL1) | 0.1396 | 0.1526 | −0.0589 | −0.2969 | −0.5082 | 0 |
| G-CSF | 0.0100 | 0.1813 | −0.0391 | −0.7962 | −2.2948 | 0 |
| GDNF | 0.0393 | 0.0590 | −0.1486 | −0.7907 | −2.2565 | 3 |
| GM-CSF | 0.0100 | 0.0739 | −0.0320 | −0.7621 | −2.0716 | 0 |
| GPC-2 (CXCL6) | 0.0466 | 0.0889 | −0.1052 | −0.6931 | −1.7041 | 0 |
| GRO a/b/g | 0.1577 | 0.0313 | −0.1014 | −0.3913 | −0.7162 | 2 |
| GRO alpha (CXCL1) | 0.0100 | 0.1253 | −0.0267 | −0.7279 | −1.8775 | 0 |
| HGF | 0.0100 | 0.1463 | −0.0363 | −0.7842 | −2.2124 | 0 |
| I-309 (CCL1) | 0.0338 | 0.5121 | −0.0289 | −0.4605 | −0.8904 | 0 |
| IFN-gamma | 0.1881 | 0.9113 | 0.0051 | 0.0281 | 0.0400 | 0 |
| IGF-1 | 0.0100 | 0.0384 | −0.0750 | −0.8824 | −3.0874 | 3 |
| IGFBP-1 | 0.0100 | 0.2575 | −0.0365 | −0.7851 | −2.2180 | 0 |
| IGFBP-2 | 0.0253 | 0.0948 | −0.0776 | −0.7542 | −2.0247 | 0 |
| IGFBP-3 | 0.1122 | 0.9345 | 0.0010 | 0.0092 | 0.0133 | 0 |
| IGFBP-4 | 0.1027 | 0.2169 | −0.0222 | −0.1774 | −0.2817 | 0 |
| IL-1 alpha (IL-1 F1) | 0.0770 | 0.8593 | −0.0083 | −0.0977 | −0.1483 | 0 |
| IL-1 beta (IL-1 F2) | 0.2268 | 0.3119 | 0.0318 | 0.1633 | 0.2182 | 0 |
| IL-10 | 0.0100 | NA | 0.0000 | 0.0000 | 0.0000 | 0 |
| IL-12 (p40/p70) | 0.1481 | 0.0983 | −0.0269 | −0.1536 | −0.2406 | 0 |
| IL-13 | 0.0654 | 0.3267 | 0.0323 | 0.9763 | 0.9828 | 1 |
| IL-15 | 0.2774 | 0.2844 | 0.0478 | 0.2081 | 0.2727 | 2 |
| IL-16 | 0.1368 | 0.2513 | −0.0505 | −0.2697 | −0.4535 | 0 |
| IL-2 | 0.1239 | 0.5033 | 0.0271 | 0.2799 | 0.3561 | 0 |
| IL-3 | 0.1964 | 0.6411 | 0.0224 | 0.1290 | 0.1751 | 0 |
| IL-4 | 0.0869 | 0.2814 | −0.0215 | −0.1984 | −0.3191 | 0 |
| IL-5 | 0.0100 | 0.1043 | −0.0978 | −0.9073 | −3.4306 | 3 |
| IL-6 | 1.8106 | 0.5854 | −0.0546 | −0.0293 | −0.0429 | 1 |
| IL-7 | 0.0100 | 0.0949 | −0.1245 | −0.9256 | −3.7491 | 4 |
| IL-8 (CXCL8) | 1.0915 | 0.9680 | 0.0061 | 0.0057 | 0.0082 | 1 |
| IP-10 (CXCL10) | 0.6526 | 0.2375 | 0.0728 | 0.1256 | 0.1707 | 4 |
| Leptin | 0.1577 | 0.2038 | −0.0463 | −0.2268 | −0.3711 | 0 |
| LIF | 0.3174 | 0.5290 | 0.0531 | 0.2011 | 0.2643 | 4 |
| LIGHT (TNFSF14) | 0.1716 | 0.7360 | −0.0059 | −0.0331 | −0.0486 | 0 |
| MCP-1 (CCL2) | 1.5040 | 0.1989 | 0.1576 | 0.1170 | 0.1596 | 4 |
| MCP-2 (CCL8) | 0.0707 | 0.0456 | −0.0596 | −0.4575 | −0.8824 | 1 |
| MCP-3 (CCL7) | 0.0100 | 0.0017 | −0.0681 | −0.8719 | −2.9649 | 2 |
| MCP-4 (CCL13) | 0.0676 | 0.1183 | −0.0606 | −0.4727 | −0.9232 | 0 |
| M-CSF | 0.0577 | 0.0341 | −0.1840 | −0.7613 | −2.0669 | 2 |
| MDC (CCL22) | 0.0100 | 0.0452 | −0.0986 | −0.9079 | −3.4404 | 1 |
| MIF | 0.0362 | 0.0042 | −0.1472 | −0.8025 | −2.3398 | 5 |
| MIG (CXCL9) | 0.0100 | 0.1174 | −0.0204 | −0.6708 | −1.6028 | 0 |
| MIP-1 beta (CCL4) | 0.2621 | 0.0575 | −0.0705 | −0.2120 | −0.3437 | 1 |
| MIP-1 delta | 0.0100 | 0.0006 | −0.0684 | −0.8725 | −2.9711 | 3 |
| MIP-3 alpha (CCL20) | 0.0100 | 0.0146 | −0.0516 | −0.8377 | −2.6232 | 1 |
| NAP-2 (CXCL7) | 0.0100 | 0.0856 | −0.0692 | −0.8737 | −2.9850 | 0 |
| NT-3 | 0.3264 | 0.3826 | −0.0320 | −0.0894 | −0.1351 | 1 |
| NT-4 | 0.0807 | 0.4584 | −0.0204 | −0.2020 | −0.3256 | 0 |
| OPG (TNFR SF 11) | 1.3666 | 0.6382 | 0.0410 | 0.0309 | 0.0439 | 1 |
| OPN (SSP1) | 0.3109 | 0.1552 | −0.0895 | −0.2235 | −0.3649 | 1 |
| OSM | 0.4078 | 0.6803 | 0.0178 | 0.0455 | 0.0642 | 1 |
| PARC | 0.1914 | 0.8600 | −0.0119 | −0.0586 | −0.0871 | 0 |
| PDGF-BB | 0.0948 | 0.3120 | −0.0265 | −0.2187 | −0.3561 | 0 |
| PLGF | 0.1465 | 0.3941 | 0.0627 | 0.7481 | 0.8058 | 0 |
| RANTES (CCL5) | 0.2646 | 0.6313 | 0.0288 | 0.1221 | 0.1662 | 1 |
| SCF | 0.1688 | 0.2936 | 0.0226 | 0.1546 | 0.2073 | 1 |
| SDF-1 alpha (CXCL12) | 0.2151 | 0.9245 | −0.0024 | −0.0112 | −0.0163 | 0 |
| TARC (CCL17) | 0.3281 | 0.5687 | −0.0430 | −0.1158 | −0.1775 | 1 |
| TGF beta 1 | 0.0544 | 0.0192 | −0.0718 | −0.5692 | −1.2149 | 1 |
| TGF beta 2 | 0.6476 | 0.0122 | 0.1226 | 0.2335 | 0.3028 | 5 |
| TGF beta 3 | 0.1224 | 0.3794 | −0.0171 | −0.1228 | −0.1890 | 0 |
| TIMP-1 | 0.6717 | 0.4984 | −0.0302 | −0.0430 | −0.0634 | 1 |
| TIMP-2 | 1.3389 | 0.1198 | −0.0474 | −0.0342 | −0.0502 | 1 |
| TNF alpha | 0.0100 | 0.0013 | −0.0729 | −0.8794 | −3.0519 | 3 |
| TNF beta (TNF SF 1B) | 0.0536 | 0.0996 | −0.0943 | −0.6377 | −1.4649 | 0 |
| TPO | 0.1176 | 0.0026 | 0.0337 | 0.4011 | 0.4865 | 4 |
| VEGF-A | 0.2579 | 0.6450 | 0.0224 | 0.0952 | 0.1312 | 1 |