Table 3.
List of pathways found in the Reactome analysis, with indication of the selected CAF-200 secretome proteins that were associated with each pathway. For reasons of space, only the first 20 pathways are listed.
| Pathway Name | Pathway Identifier | Proteins from Study Found in Pathway | no. Proteins in Study (Total) |
|---|---|---|---|
| Immune System | R-HSA-168256 | AP1B1, CCL2, CTSA, DNAJC3, HMGB1, HSP90AA1, HSP90AB1, PA2G4, S100A11, TXN, YWHAZ | 11 (2895) |
| Innate Immune System | R-HSA-168249 | CTSA, DNAJC3, HMGB1, HSP90AA1, HSP90AB1, PA2G4, S100A11, TXN | 8 (1331) |
| Neutrophil degranulation | R-HSA-6798695 | CTSA, DNAJC3, HMGB1, HSP90AA1, HSP90AB1, PA2G4, S100A11 | 7 (480) |
| Disease | R-HSA-1643685 | AP1B1, APOA1, CTSA, DNAJC3, HSP90AA1, HSP90AB1, TXN | 7 (2512) |
| Signal Transduction | R-HSA-162582 | APOA1, CCL2, HSP90AA1, HSP90AB1, SERPINE1, YWHAH, YWHAZ | 7 (3421) |
| Metabolism of proteins | R-HSA-392499 | APOA1, CCL2, CTSA, DNAJC3, EIF3F, TXN | 6 (2355) |
| Vesicle-mediated transport | R-HSA-5653656 | AP1B1, APOA1, HSP90AA1, YWHAH, YWHAZ | 5 (825) |
| Infectious disease | R-HSA-5663205 | AP1B1, DNAJC3, HSP90AA1, HSP90AB1, TXN | 5 (1468) |
| Gene expression (Transcription) | R-HSA-74160 | HSP90AA1, SERPINE1, TXN, YWHAH, YWHAZ | 5 (1851) |
| Metabolism | R-HSA-1430728 | APOA1, CTSA, HSP90AA1, HSP90AB1, TXN | 5 (3658) |
| Programmed Cell Death | R-HSA-5357801 | HMGB1, HSP90AA1, YWHAH, YWHAZ | 4 (218) |
| Cell Cycle | R-HSA-1640170 | HSP90AA1, HSP90AB1, YWHAH, YWHAZ | 4 (734) |
| Signalling by Interleukins | R-HSA-449147 | CCL2, HMGB1, HSP90AA1, YWHAZ | 4 (647) |
| Cytokine Signalling in Immune system | R-HSA-1280215 | CCL2, HMGB1, HSP90AA1, YWHAZ | 4 (1332) |
| Generic Transcription Pathway | R-HSA-212436 | SERPINE1, TXN, YWHAH, YWHAZ | 4 (1554) |
| RNA Polymerase II Transcription | R-HSA-73857 | SERPINE1, TXN, YWHAH, YWHAZ | 4 (1693) |
| TP53 Regulates Metabolic Genes | R-HSA-5628897 | TXN, YWHAH, YWHAZ | 3 (125) |
| HSP90 chaperone cycle for steroid hormone receptors (SHR) | R-HSA-3371497 | HSP90AA1, HSP90AB1 | 2 (80) |
| Resistance of ERBB2 KD mutants to trastuzumab | R-HSA-9665233 | HSP90AA1 | 1 (5) |
| Drug resistance in ERBB2 TMD/JMD mutants | R-HSA-9665737 | HSP90AA1 | 1 (5) |