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. 2021 Dec 5;13(12):2090. doi: 10.3390/pharmaceutics13122090

Table 5.

LNP carriers of the COVID-19 mRNA vaccines (lipidic constituents) [130,131].

Lipid Name Role Abbreviation Molar Lipid Ratios (%) (Ionizable Cationic Lipid:Neutral Lipid:Cholesterol:PEG-ylated Lipid)
BNT162b2 vaccine
4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate ionizable cationic lipid ALC-0315 46.3:9.4:42.7:1.6
1,2-Distearoyl-sn-glycero-3-phosphocholine helper lipid DSPC
cholesterol helper lipid Chol
2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide PEG-lipid ALC-0159
mRNA-1273 vaccine
heptadecan-9-yl 8-((2-hydroxyethyl)[6-oxo-6-(undecyloxy)hexyl]amino)octanoate ionizable cationic lipid SM-102 50:10:38.5:1.5
1,2-distearoyl-sn-glycero-3-phosphocholine helper lipid DSPC
cholesterol helper lipid Chol
1,2-Dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 PEG-lipid PEG2000-DMG