Table 2.

Examples of interventions targeting microglial phagocytosis, which are of benefit in stroke models.

Ref.	Stroke Model	Intervention	Reduced Levels of
[43]	Transient, focal ischemia induced by endothelin 1 in mice	MFG-E8 knockout	Brain atrophy and motor deficits at 28 days
[43]	Transient, focal ischemia induced by endothelin 1 in rats	MerTK knockout	Brain atrophy and motor deficits at 28 days
[65]	Collagenase-induced intracerebral hemorrhage	MerTK knockout in microglia	Brain atrophy and motor deficits at 14 days
[65]	Transient MCAO in mice	MerTK knockout in microglia	Brain atrophy and motor deficits at 14 days
[66]	Transient MCAO in rats	RGD-peptides inhibiting αvβ3	Infarct and motor deficits at 2 days
[45]	Transient MCAO in rats	TMEM16F knockdown	Neuron loss at 3 days Motor deficits 14 days
[64]	Transient MCAO in rats and mice	MicroRNA-98 overexpression	Neuron loss and neuro-deficits at unclear time
[55]	Transient MCAO in mice	C1q-blocking protein sCR1	Neuro-deficits 1 day, infarct at 3 days
[60]	Transient MCAO in mice	C3 knockout	Infarct and neurological deficits at 1 day
[60]	Transient MCAO in mice	C3a-receptor antagonist	Infarct and neurological deficits at 1 day
[61]	Transient MCAO in mice	C3 inhibitor Crry	Neuron loss and neurodeficits at 15 days
[62]	Embolic MCAO in mice	C3 inhibitor Crry	Synapse loss and cognitive deficits at 30 days
[50]	dMCAO + hypoxia model of 2ry neurodegeneration in mice	Osteopontin knockout	Motor deficits 14 days, neuron loss at 49 days
[63]	Transient global brain ischemia in mice	GD3 synthase knockout	Neuron loss at 4 days
[36]	Transient global brain ischemia in mice	P2Y12 knockout or inhibition	Neuron loss at 3 days