Table 2.
Allotransplantation (Animal Transplantation within the Same Species) | |||||||
---|---|---|---|---|---|---|---|
Case No. | Aim | Cell Source | Host | Scaffold/Cell Sheet | Growth Factor | Results | Article |
1. | Exploration of the therapeutic effects of DPSCs on acute radiation-induced oesophageal injury | rat DPSC isolated from the incisors | 33 rats with acute radioactive oesophageal injuries induced by radioactive 125I seeds in vivo | The OriCellTM osteogenesis differentiation kit was used to induce osteogenic differentiation. P3 SCs were cultured in osteogenic differentiation medium Adipogenesis was induced by using the OriCellTM adipogenic differentiation kit (injected with DPSCs (1 × 107 cells) |
The results demonstrated that transplanted DPSCs, which trans-differentiated into esophageal stem cells in vivo, could repair the damaged esophageal tissue | [91] | |
2. | Investigation of the therapeutic potential of DPSCs for ischemic vascular diseases and opportunity for neural regeneration | DPSCs was harvested from the incisors of 4-week-old male SD rats | 24 rats with middle cerebral artery occlusion (MCAO) | Intravenous infusion of DPSCs | Neuroprotective effect on brain ischemia rats, by reducing the infarct volume and enhancing the neurological function recovery after cerebral ischemic injury | [92] | |
3. | Verification of DPSCs proliferation and osteogenic differentiation in a three-dimensional cell culture using SPG-178-Gel | DPSCs isolated from the dental pulp of extracted incisors of six-week-old male Sprague-Dawley (SD) rats | 24 h-week-old male Sprague-Dawley (SD) rats with the calvarial defect | self-assembling peptide hydrogel, SPG-178-Gel, | Osteogenic induction medium containing recombinant human bone morphogenetic protein-4 (rhBMP-4) in a two-dimensional cell culture | In conclusion, DPSCs + SPG-178-Gel can be a suitable tool for bone formation in vivo and in vitro | [93] |
4. | Evaluation of the osteogenic effects of dense collagen gel scaffolds seeded with rat DPSC (rDPSC) implanted in a rat critical-sized calvarial defect model | DPSC isolated from the molars of 4-day Wistar rats | 30 rats with critical-size calvarial defect model | dense collagen gel scaffolds | Bone mineral density and bone micro-architectural parameters were significantly increased when DPSC-seeded scaffolds were used | [94] | |
5. | Comparison of the osteogenic differentiation of bone marrow-derived mesenchymal stromal cells and dental pulp-derived stromal cells (DPSCs) in vitro and in a pig calvaria critical-size bone defect model | DPSCs isolated from the premolar from the upper and lower pig jaw, BMSCs was aspirated from the proximal tibia | 28 pigs with critical-size calvarial defect model | a three-dimensional (3D) polycaprolactone (PCL)–hyaluronic acid–tricalcium phosphate (HT–PCL) scaffold. | DPSCs exhibited a higher osteogenic potential compared with BMSCs both in vitro and in vivo, making it a potential cell source for future bone tissue engineering | [95] | |
6. | Assessment of the therapeutic potential of DPSCs transplant in the case of diabetic polyneuropathy | DPSCs isolated from the dental pulp of extracted incisors of Sprague-Dawley rats | 10 points of normal and diabetic rats | Transplantation of DPSCs could be a promising tool for the treatment of diabetic neuropathy | [125] | ||
7. | Evaluation of the therapeutic potential of mDPSCs in important complications of diabetes, namely pancreatic damage, renal function alterations and diabetic peripheral neuropathy | DPSCs DPSCs isolated from the incisor teeth of male EGFP transgenic C57BL/6 mice | 12 diabetic mice | Endovenous transplantation | Improved pancreatic damage, renal function and painful neuropathy |
[126] |