Table 3.
(A) Autotransplantation (animal autologous transplantation). (B) Autotransplantation (human autologous transplantation).
| (A) | |||||||
| Autotransplantation (Animal Autologous Transplantation) | |||||||
| Case No. | Aim | Cell Source | Host | Scaffold/Cell Sheet | Growth Factor | Results | Article |
| 1. | The demonstration for the first time of complete pulp regeneration in the root canal, after pulpectomy, in dogs | Dog CD105+ DPSCs |
5 dogs after pulpectomy in mature teeth | a collagen scaffold | stromal cell-derived factor-1 (SDF-1) | Complete pulp regeneration with neurogenesis and vasculogenesis occurred | [96] |
| 2. | Evaluation of effects of dental pulp stem cells (DPSCs) on regeneration of a defect experimentally created in the periodontium of a canine model | DPSCs isolated from 2 maxillary premolar dog teeth | 20 dogs | Bio-Oss | DPSCs are capable of promoting periodontal regeneration | [97] | |
| 3. | Demonstration of the neuronal differentiation of DPSC from murine incisors | DPSCs isolated from murine incisor teeth | murine | mouse-specific fibroblast growth factor-2 (FGF-2) mouse-specific nerve growth factor (NGF) |
Generated neuronal-like cells from murine incisor DPSC to an immature stage of development. Our findings encourage the use of mDPSC to develop mouse models of autologous neural therapeutic transplantations for pre-clinical studies. | [106] | |
| 4. | Evaluation of the capacity of a Tissue-engineered bone complex of recombinant human bone morphogenetic protein 2 (rhBMP-2)-mediated rabbit dental pulp stem cells (DPSCs) and nano-hydroxyapatite/collagen/poly(L-lactide) (nHAC/PLA) to reconstruct critical-size alveolar bone defects in New Zealand rabbit | DPSCs from New Zealand white rabbit | 36 rabbits with critical-size alveolar bone defects | scaff-nano-hydroxyapatite/collagen/poly(L-lactide) (nHAC/PLA) | bone morphogenetic protein 2 (rhBMP-2)-mediated dental pulp stem cells (DPSCs) | The rhBMP-2 promoted osteogenic capability of DPSCs as a potential cell source for periodontal bone regeneration. DPSCs might be a better alternative to autologous bone for the clinical reconstruction of periodontal bone defects. | [107] |
| (B) | |||||||
| Autotransplantation (Human Autologous Transplantation) | |||||||
| Case No. | Aim | Cell Source | Host | Scaffold/Cell Sheet | Growth Factor | Results | Article |
| 1. | Evaluation of the safety, potential efficacy and feasibility of autologous transplantation of MDPSCs in pulpectomised teeth | DPSCs isolated from discarded teeth | 5 patients with irreversible pulpitis | atelocollagen | granulocyte colony-stimulating factor (G-CSF) | Pulp regeneration, functional dentin formation in three of the five patients | [39] |
| 2. | Trying to isolate of DPSCs-IPs from two patients and to evaluate the feasibility and the effect of reconstructing periodontal intrabone defects in each patient | DPSCs-IPs derived from inflammatory dental pulp tissues | 2 patientswith cells engrafted into the periodontal defect area in the root furcation. | β-tricalcium phosphate (β-TPC | - | Regeneration of new intrabony defect | [131] |
| 3. | The description of the clinical and radiographic regenerative potential of autologous DPSCs in the treatment of human uncontained intraosseous defects | DPSCs collected from deciduous teeth | 1 patient | - | The defect was completely filled with bonelike tissue | [132] | |
| 4. | To show that implantation of autologous tooth stem cells from deciduous teeth regenerated dental pulp with an odontoblast layer, blood vessels and nerves | DPSCs isolated from deciduous teeth | 40 patients with pulp necrosis after traumatic dental injuries | extracellular matrix | - | Regeneration of dental pulp tissue containing sensory nerves | [133] |