Table 2.
Patients’ baseline and peak liver function tests as well as cardiac biomarkers in each subgroup.Using propensity score matching, we found significantly higher levels of ALT, ALKP and GGT in the group with the worst cardiac function parameters compared to controls. Level of AST was also higher in that group, although not significantly.
| All Patients, n = 1339 | CVP ≤ 10 mm/Hg and EF ≥ 45% n = 853 |
CVP ≤ 10 mm/Hg and EF < 45% n = 364 |
CVP > 10 mm/Hg and EF ≥ 45% n = 61 |
CVP > 10 mm/Hg and EF < 45% n = 61 |
p Value | |
|---|---|---|---|---|---|---|
| ALT first, median (U/L) IQR | 29 (20–45) | 29 (21–44) | 35 (23–54) | 46 (21–73) | 41 (26–88) | 0.000 |
| ALT max median (U/L) IQR | 33 (22–53) | 31 (22–47) | 40 (27–64) | 52 (25–82) | 59 (31–107) | 0.000 |
| AST first median (U/L) IQR | 74 (35–157) | 55 (31–120) | 86 (40–199) | 103 (43–222) | 143 (46–290) | 0.000 |
| AST max median (U/L) IQR | 78 (38–175) | 57 (33–121) | 100 (44–229) | 141 (54–272) | 207 (56–493) | 0.000 |
| Total bilirubin—first median (U/L) IQR | 0.5 (0.4–0.7) | 0.5 (0.4–0.7) | 0.5 (0.4–0.7) | 0.5 (0.4–0.8) | 0.6 (0.4–0.9) | 0.000 |
| Total bilirubin—max median (U/L) IQR | 0.58 (0.4–0.8) | 0.5 (0.4–0.72) | 0.58 (0.4–0.8) | 0.6 (0.48–1) | 0.6 (0.4–0.9) | 0.000 |
| Bilirubin indirect—first median (U/L) IQR | 0.4 (0.2 – 0.5) | 0.4 (0.3–0.5) | 0.4 (0.3 – 0.5) | 0.4 (0.2–0.7) | 0.3 (0.2–0.6) | 0.638 |
| Bilirubin indirect—max median (U/L) IQR | 0.4 (0.3–0.5) | 0.4 (0.3–0.5) | 0.4 (0.3–0.6) | 0.4 (0.2–0.7) | 0.3 (0.2–0.6) | 0.559 |
| Bilirubin direct—first median (U/L) IQR | 0.2 (0.1–0.3) | 0.2 (0.1–0.3) | 0.2 (0.1–0.3) | 0.2 (0.1–0.3) | 0.25 (0.14–0.4) | 0.143 |
| Bilirubin direct—max median (U/L) IQR | 0.2 (0.1–0.3) | 0.2 (0.1–0.3) | 0.2 (0.1–0.3) | 0.3 (0.1–0.5) | 0.3 (0.1–0.5) | 0.026 |
| ALP first median (U/L) IQR | 68 (56–82) | 70 (58–82) | 71 (58–86) | 72 (58–87) | 72 (60–98) | 0.273 |
| ALP max median (U/L) IQR | 70 (57–84) | 71 (58–84) | 74 (61–90) | 79 (59–91) | 85 (62–115) | 0.000 |
| GGT first median (U/L) IQR | 28 (18–50) | 27 (17–42) | 28 (17–55) | 34 (17–63) | 46 (25–112) | 0.005 |
| GGT max median (U/L) IQR | 30 (19–52) | 28 (17–46) | 31 (18–58) | 53 (17–162) | 54 (30–123) | 0.001 |
| CRP, median (mg/L) IQR | 4 (1–12) | 4 (1–9) | 5 (2–13) | 7 (2–17) | 8 (3–25) | 0.000 |
| CRP-max, median (mg/L) IQR | 21 (9–61) | 10 (4–27) | 33 (10–116) | 56 (10–139) | 78 (26–168) | 0.000 |
| CPK (peak), median (U/L) IQR | 760 (281–1664) | 723 (312–1443) | 1302 (500–2762) | 839 (371–1672) | 1112 (399–2682) | 0.000 |
| Troponin first median (mg/dL) IQR | 13 (0.2–333) | 0.11 (0.02–1.58) | 0.4 (0.07–4.3) | 2 (0.06–13) | 1.2 (0.1–13) | 0.000 |
| Troponin max median (mg/dL) IQR | 145 (6–42833) | 21 (5–60) | 50 (15–163) | 41 (18–80) | 65 (15–165) | 0.000 |