Table A1.

Significantly altered metabolites after the drug treatment. Student’s t-test was performed to evaluate the statistical significance of changes in metabolite levels. Bold indicates that the changed metabolites are statistically significant.

Metabolite	Fasnall			IU1			Fasnall + IU1
	p -Value	Fold Change	Trend	p -Value	Fold Change	Trend	p -Value	Fold Change	Trend
Asparagine	<0.001	1.55	up	NS	1.18	up	<0.0005	2.892	up
Citric acid	<0.001	0.92	down	NS	1.36	up	<0.005	0.55	down
Citrulline	<0.05	1.04	up	NS	1.11	up	<0.0005	0.61	down
Glutamic acid	NS	0.94	down	NS	0.94	down	<0.005	0.616	down
Glutathione	NS	0.98	down	NS	0.93	down	<0.0001	0.493	down
Arginine	<0.01	1.52	up	<0.01	4.7	up	<0.05	4.014	up
Leucine	NS	2.82	up	NS	1.42	up	<0.05	2.318	up
Histidine	<0.0001	1.15	up	<0.05	1.4	up	<0.01	1.997	up
Threonine	<0.0001	2.24	1.24	<0.05	1.26	up	<0.01	1.686	up
Tryptophan	<0.01	2.51	up	<0.01	1.96	up	<0.0001	5.028	up
Tyrosine	<0.05	1.42	up	NS	1.26	up	<0.001	2.36	up
N-Acetylaspartylglutamic acid	<0.001	1.14	up	NS	0.98	down	NS	0.959	down
N-Acetyl-DL-alanine	<0.0001	1.23	up	NS	1.03	up	<0.0001	1.651	up
N-Acetyl-DL-aspartic acid	NS	1.04	up	<0.05	0.9	down	<0.05	0.858	down
N-Acetyl-DL-glutamic acid	NS	0.98	down	NS	1.05	up	NS	0.474	down
Nicotinamide	<0.001	0.94	down	<0.05	0.71	down	<0.001	0.475	down
N-Methylglutamic acid	<0.05	2.28	up	<0.05	1.78	up	<0.0001	4.728	up
Pantothenic acid	<0.05	1.12	up	NS	0.87	down	<0.05	1.148	up
Tyramine	<0.05	1.81	up	<0.05	1.47	up	<0.05	2.048	up
Saccharopine	<0.001	1.15	up	<0.05	1.29	up	NS	1.058	up
2-Furoglycine	<0.05	1.04	up	NS	1.02	up	<0.05	0.801	down
12-Hydroxydodecanoic acid	<0.001	15.32	up	NS	0.74	down	<0.0001	53.337	up
9-oxo-10E,12Z-octadecadienoic acid	NS	1.42	up	NS	0.35	down	NS	5.502	up
Arachidonic acid	<0.001	1.29	up	NS	0.44	down	<0.05	7.322	up
Adrenic acid	NS	0.96	down	<0.0001	0.56	down	<0.05	1.996	up
Arachidonic acid-(2-aminoethyl)-ester	NS	1.41	up	<0.05	2.08	up	NS	1.718	up
Dihomo-alpha-linolenic acid	<0.001	1.16	up	<0.005	0.43	down	<0.05	3.825	up
Dihomo-gamma-linolenic acid	NS	2.65	up	NS	5.12	up	NS	3.153	up
Palmitic acid	NS	1.32	up	<0.0001	3.63	up	<0.001	2.044	up
Stearic acid	<0.001	1.37	up	<0.0001	3.43	up	<0.05	2.046	up
Oleoyl-L-carnitine	<0.0001	31.96	6.922	NS	1.56	up	<0.0001	27.781	up
Palmitoyl-L-carnitine	<0.001	9.85	up	<0.05	2.89	up	<0.0001	39.377	up
Riboflavin	<0.05	1.23	up	NS	1.2	up	<0.05	1.335	up
6-Hydroxyflavone	<0.001	1.36	up	NS	1.57	up	<0.05	2.479	up
Glycerophosphocholine	<0.01	0.83	down	NS	1.12	up	<0.001	0.286	down
2-deoxy-2-thio Arachidonoyl PC	<0.05	1.01	up	NS	1.2	up	NS	1.268	up
LysoPC(18:1/0:0)	<0.001	1.14	up	<0.0001	3.74	up	<0.001	1.821	up
LysoPC(18:0/0:0)	<0.001	1.65	up	<0.0001	7.87	up	<0.05	3.069	up
LysoPE(16:0/0:0)	<0.0001	1.46	up	<0.0001	2.46	up	<0.001	3.355	up
LysoPE (22:6/0:0)	NS	1.12	up	NS	1.04	up	<0.05	1.325	up
LysoPE alkenyl (18:1)	<0.001	1.19	up	<0.05	1.34	up	<0.05	1.431	up
PC (18:1/2:0)	<0.001	1.2	up	<0.0001	10.76	up	<0.001	2.914	up
PC (30:1)	<0.005	1.21	up	NS	1.13	up	<0.05	1.357	up
PC (36:5)	NS	0.673	down	NS	0.56	down	NS	0.509	down
PC (16:0/0:0)	<0.0001	1.16	up	<0.0001	5.15	up	<0.0001	2.119	up
PE (18:1/0:0)	<0.0001	2.28	up	<0.0001	2.95	up	<0.05	1.649	up
Malic acid	<0.05	1.04	up	NS	0.87	down	NS	0.892	down
5’-Deoxy-5’-methylthioadenosine	<0.05	0.97	down	<0.05	1.33	up	NS	1.178	up
Adenosine monophosphate (AMP)	<0.001	1.49	up	<0.05	1.48	up	<0.001	3.897	up
Guanosine monophosphate (GMP)	<0.0001	1.49	up	<0.05	0.64	down	<0.001	2.445	up
Uridine monophosphate (UMP)	<0.05	1.42	up	NS	1.1	up	<0.05	2.365	up
Taurine	<0.001	2.13	up	NS	1.17	up	<0.0001	3.387	up
Phosphocholine	<0.0001	2.134	up	<0.01	3.1	up	<0.05	4.275	up
Hydroxyphenyllactic acid	<0.01	2.7	up	<0.05	1.51	up	<0.0001	5.856	up
Cholic acid	<0.05	1.37	up	NS	1.21	up	<0.0001	1.944	up