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. 2021 Dec 12;22(24):13353. doi: 10.3390/ijms222413353

Figure 4.

Figure 4

Ligand-protein interactions in static structures of the MOR. (a) Water-mediated H-bond network of H6.52 in the structure of BU72-bound MOR. The agonist BU72 H-bonds to H6.52 via two waters. The H-bond network includes K5.39 and Y3.33. D3.32 is close to the ligand. The molecular graphics is based on structure PDB ID:5C1M [32]. (b) Binding site interactions of DAMGO. Protein groups shown have at least one side chain atom within 4 Å of DAMGO. The closest atoms between DAMGO and MOR groups shown are connected with dotted lines. Molecular graphics based on PDB ID:6DDF [34] were prepared using UCSF Chimera 1.14 [23] and the text and dotted lines were added with Inkscape 1.0.