Table 4.
Absorbed dose estimates of [177Lu]Lu-DOTA.SA.FAPi and [177Lu]Lu-DOTAGA.(SA.FAPi)2.
| [177Lu]Lu-DOTA.SA.FAPi | [177Lu]Lu-DOTAGA.(SA.FAPi)2 | ||
|---|---|---|---|
| Organ | Mean Absorbed Doses (Gy/GBq) | Organ | Mean Absorbed Doses (Gy/GBq) |
| Adrenals | 7.79E-03 ± 3.69E-04 | Adrenals | 1.27E-02 ± 4.63E-03 |
| Brain | 2.06E-05 ± 2.09E-05 | Brain | 1.17E-04 ± 3.93E-05 |
| Breasts | 4.39E-04 ± 2.64E-04 | Breasts | 6.39E-04 ± 5.30E-05 |
| Esophagus | 1.80E-03 ± 9.12E-04 | Esophagus | 3.07E-03 ± 6.35E-04 |
| Eyes | 2.13E-05 ± 2.04E-05 | Eyes | 9.96E-05 ± 4.11E-05 |
| Gallbladder Wall | 6.06E-03 ± 1.91E-04 | Gallbladder Wall | 7.95E-01 ± 2.58E-01 |
| Left colon | 4.30E-01 ± 9.40E-02 | Left colon | 2.87E+00 ± 1.74E+00 |
| Small Intestine | 2.71E-03 ± 1.74E-04 | Small Intestine | 9.24E-03 ± 4.92E-03 |
| Stomach Wall | 2.03E-03 ± 3.74E-04 | Stomach Wall | 6.62E-03 ± 1.84E-03 |
| Right Colon | 4.72E-01 ± 3.93E-02 | Right Colon | 1.16E+00 ± 8.58E-01 |
| Rectum | 5.08E-04 ± 5.31E-05 | Rectum | 2.02E-03 ± 1.04E-03 |
| Heart Wall | 1.40E-03 ± 1.09E-03 | Heart Wall | 2.57E-03 ± 1.39E-03 |
| Kidneys | 6.18E-01 ± 1.54E-02 | Kidneys | 3.74E-01 ± 2.57E-01 |
| Liver | 1.15E-01 ± 9.02E-03 | Liver | 2.09E-01 ± 2.38E-02 |
| Lungs | 6.10E-02 ± 1.04E-01 | Lungs | 2.21E-03 ± 5.66E-04 |
| Ovaries | 9.08E-04 ± 7.3E-05 | Ovaries | 2.23E-03 ± 2.50E-04 |
| Pancreas | 3.69E-03 ± 2.33E-04 | Pancreas | 6.51E-01 ± 1.37E-01 |
| Prostate | - | Prostate | 2.57E-03 ± 1.35E-03 |
| Salivary glands | 6.56E-05 ± 6.79E-05 | Salivary glands | 1.17E-01 ± 9.53E-03 |
| Red Marrow | 9.84E-04 ± 2.58E-04 | Red Marrow | 1.73E-02 ± 1.82E-02 |
| Osteogenic Cells | 1.18E-03 ± 2.89E-04 | Osteogenic Cells | 8.57E-03 ± 6.95E-03 |
| Spleen | 3.99E-03 ± 2.18E-04 | Spleen | 6.36E-03 ± 1.52E-03 |
| Testes | - | Testes | 1.71E-04 ± 9.97E-05 |
| Thymus | 1.22E-03 ± 1.49E-03 | Thymus | 1.00E-03 ± 3.09E-04 |
| Thyroid | 4.53E-04 ± 5.25E-04 | Thyroid | 3.98E-04 ± 8.53E-05 |
| Urinary Bladder Wall | 4.05E-04 ± 4.12E-05 | Urinary Bladder Wall | 1.28E-03 ± 4.29E-04 |
| Uterus | 7.84E-04 ± 7.47E-04 | Uterus | 2.18E-03 ± 2.70E-04 |
| Total Body | 1.10E-02 ± 1.72E-03 | Total Body | 2.33E-02 ± 6.15E-03 |
All values are mentioned as mean ± SD.