Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 20;22(24):13650. doi: 10.3390/ijms222413650

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

HRD and BRCA1/2 mutation in HGSOC. Approximately 50% of HGSOCs have homologous recombination deficiency (HRD). Among genes, BRCA1/2 are the most common involved: about 14% of HGSOC patients were reported to have BRCA1/2 mutation detectable in a blood sample (germinal mutation, analysis of peripheral Lymphocytes). While a BRCA1/2 mutation found only in a tissue sample is present in about 20% of the affected women (somatic mutation). Other genes with a role in HRD are CDK12 (3% of cases), RAD51C (2%), EMSY (6%), and PTEN (7%).