Table 2.

Discussed circulating biomarkers in OC.

Type of Circulating Biomarker
Glycoprotein Biomarkers	CA 125
	HE4
	Mesothelin
Liquid Biopsy	ctDNA
	CTCs
	EVs
Epigenetic and Genetic Markers	miRNA
	DNA methylation
	Histone modification
	TP53 mutation
	HRD-BRCA1/2 mutation
Immune-Related Biomarkers	NLR
	PLR
	Circulating T-cell
	Circulating B-cell
	sPD-1/sPD-L1
	MDSC4
	NMLR
Angiogenic Markers	sVEGF

Abbreviations: BRCA Breast Cancer susceptibility gene, CTCs Circulating Tumor Cells, ctDNA Circulating Tumor DNA, EVs Extracellular Vesicles, HE Human Epididymis Protein 4, HRD Homologous Recombination Deficiency, MDSC4 Circulating Myeloid-Derived Suppressor Cells type 4, miRNAs Micro RNAs, NLR Neutrophil-Lymphocyte ratio, NMLR Neutrophil-and-Monocyte to Lymphocyte Ratio, PLR Platelet-Lymphocyte Ratio, sPD-1 soluble form of Programmed Cell Death Protein 1, sPD-L1 soluble form of Programmed cell Death Protein Ligand 1, sVEGF soluble form of Vascular Endothelial Growth Factor.