Table 2.
Alignment of the amino acid sequence of the mammalian tachykinin and their preferences for tachykinin receptors [99]. The role of NKA receptors in asthma.
| Peptide (Sequence) | Affinity [99] | Activation of NKA Receptors | |
|---|---|---|---|
| SP (RPKPQQFFGLM) | NK1 > NK2 >> NK3 | NK1 ↑ inflammatory cells recruitment [100,101] |
NK1, NK2, NK3 ↑ airway smooth muscle constriction [102,103] |
| NKA (HKTDSFVGLM) | NK2 > NK 3> NK1 | ||
| NKB (DMHDFFVGLM) | NK3 > NK2 | ||
| HK1 (RSRTRQFYGLM) | NK1 >> NK2 >> NK3 | ||
| Endokinin (A/B GKASQFFGLM) | NK1 > NK2 >> NK3 | ||
| Endokinin C (KKAYQLEHTFQGLL) | NK3 | ||
| Endokinin D (VGAYQLEHTFQGLL) | NK3 | ||