Table 2.

ADMET properties of the top 10 compounds.

S. No.	Compound	Absorption		Distribution	Metabolism	Excretion	Toxicity
		GI Absorption	Water Solubility	BBB Permeation	CYP2D6 Substrate/Inhibitor	OCT2 Substrate	AMES/Hepatotoxicity
1.	Hydroxysanguinarine	High	Moderate	Yes	No	No	Yes
2.	Cepharadione A	High	Moderate	Yes	No	No	Yes
3.	Semiglabrinol	High	Moderate	Yes	No	No	No
4.	Dihydrosanguinarine	High	Moderate	Yes	No	No	Yes
5.	Curcusone A	High	Moderate	Yes	No	Yes	No
6.	Liriodenine	High	Moderate	Yes	Yes	No	No
7.	Corysamine	High	Moderate	Yes	Yes	Yes	Yes
8.	Ushinsunine	High	High	Yes	Yes	No	Yes
9.	Irenolone	High	Moderate	Yes	Yes	No	Yes
10.	Crinasiatine	High	Moderate	Yes	Yes	No	Yes

S. No., serial number; GI absorption, gastrointestinal absorption; BBB permeation, blood-brain barrier permeation.