Table 2.
Bioactivity records of the main identified compounds at level 3 in Streptomyces sp. strain CLIVUS-G1225.
| ID a | Name | cLogP | Previously Described Bioactivities |
|---|---|---|---|
| 4 | Bacillamidin C | 3.191 | Antimicrobial, non-cytotoxic (evaluated against HepG2, A549, MDA-MB-231, SGC7901) [58]. |
| 7 | Metacridamide A | 8.213 | Cytotoxic against Caco-2, MCF-7, HepG2/C3A [53]. |
| 10 | Sideromycin A | −1.133 | Antimicrobial [49]. |
| 11 | Periconiasin J | 3.132 | Anti-HIV, non-cytotoxic (evaluated against MCF-7) [54]. |
| 12 | Glomecidin | −2.695 | Antifungal [50]. |
| 13 | Erythrazole A | 6.946 | Non-cytotoxic (evaluated against non-small cell lung cancer cell lines) [59]. |
| 14 | Tris(2,4-di-tert-butylphenyl)phosphate | 13.777 | Anti-inflammatory [61]. |
| 15 | Icosalide B | 2.551 | Antiviral and moderate cytotoxic activities (evaluated against MDCK cells) [55]. |
a Only eight compounds, namely 4, 7, 10, 11, 12, 13, 14, and 15 could be putatively identified (i.e., level 3 according to Schymanski et al. [48]) in the G1225 extract.