AUC	area under the receiver operating characteristic curve
BPH	benign prostatic hyperplasia
cfDNA/cfRNA	cell free DNA/RNA
CRPC	castration resistant prostate cancer
csPCa	clinically significant prostate cancer
CTCs	circulating tumor cells
ctDNA	circulating tumor DNA
DRE	digital rectal examination
EE	early endosome
EPS	expressed prostatic secretions
ERG	ETS-related gene
EVs	extracellular vesicles
FFPE	formalin-fixed paraffin-embedded
fPSA	free PSA
KLK2	kallikrein 2
LEs	late endosomes
mpMRI	multi-parametric magnetic resonance imaging
MRI	magnetic resonance imaging
MS	mass spectrometry
MV	micro vesicle
MVBs	multivesicular bodies
p2PSA	a PC-specific fPSA isoform
PCa	prostate cancer
PSA	prostate-specific antigen
SEC	size exclusion chromatography
SP	seminal plasma
SWATH-MS	sequential Window Acquisition of all Theoretical Mass Spectra
tPSA	total PSA
TMAs	tissue microarrays
TRAQ	isobaric tag for relative and absolute quantitation
TRUS	transrectal ultrasound
uEVs	urine extracellular vesicles