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. 2021 Dec 10;22(24):13317. doi: 10.3390/ijms222413317

Figure 1.

Figure 1

Early-stage small molecules with established drug targets for dormant M. tuberculosis. Compound 1: 1-(2,4-dichlorophenyl)-3-(isoxazol-5-yl)urea; compound 2: 1-(4-fluorophenyl)-3-(isoxazol-5-yl)urea; compound 3: 7-bromo-5-chloroquinolin-8-ol; compound 4: 4-methoxy-2-(pyridin-4-yl)thiazole-5-carboxylic acid; compound 5: 1-((4-methoxyphenyl)sulfonyl)-4′,5′-dihydrospiro[piperidine-4,7′-thieno[2 ,3-c]pyran]; compound 6: 2,2′-oxybis(N′-(4-fluorobenzylidene)acetohydrazide); compound 7: 4-(5-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)thiophen-2-yl)isophthalic acid; compound 8: 4-(2-bromophenyl)-2-hydroxy-4-oxobut-2-enoic acid; compound 9: methyl ester of -4-(2-chloro-6-fluoro-3-methylphenyl)-2-hydroxy-4-oxobut-2-enoic acid; compound 10: tert-butyl ester of 3-carbamoyl-2-(4-chlorobenzamido)-4,7-dihydrothieno[2,3-c]pyridine-6(5H)-carboxylic acid; compound 11: N2,N4-bis(benzo[d]thiazol-2-yl)-1-(isonicotinamido)azetidine-2,4-dicarboxamide; compound 12: 2-ethyl-N-phenethyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine; compound 13: 3-(3-(3,4-dichlorophenyl)ureido)benzoic acid; compound 14: methyl ester of 1-hydroxy-6-thioxo-1,6-dihydropyridine-3-carboxylic acid; compound 15: ethyl ester of 1-hydroxy-6-thioxo-1,6-dihydropyridine-3-carboxylic acid; compound 16: 1-hydroxy-5-(trifluoromethyl)pyridine-2(1H)-thione.