Figure 6.

Schematic depiction of pathways detected in plasma MV by pathway analysis. Glycerophospholipid metabolism (a): relevant metabolites detected by metabolomics were involved in the enzymatic reaction catalyzed by lecithin-cholesterin acyl transferase (LCAT) and lysophosphatidylcholine acyltransferase (LPCAT).Changes in (a) were detected comparing the controls to all breast cancer patients and to the subgroup luminal B. Ether lipid metabolism (b): pathway analysis suggested involvement in the reaction catalyzed by LPCAT or phospholipase 2 when comparing metabolites of the control group to subgroup luminal B.