Figure 5.

Glucosamine-based supramolecular nanotube formation and research strategy for stem cell therapy. PFB-F-Glu (pentafluorobenzyl-phenylalanine-glucosamine) nanotubes are shown to enhance hMSC (human mesenchymal stem cells) proliferation while maintaining their pluripotency. The hMSCs cultured on PFB-F-Glu nanotubes could secrete paracrine factors to suppress pro-fibrotic gene expression in lipopolysaccharide (LPS)-treated human skin fibroblasts (WS1), indicating the nanotubes have the potential for wound healing treatment. OCT4: octamer-binding transcription factor 4; SOX2: SRY (sex determining region Y)-box 2; COLA1: collagen α1 chain; CTGF: connective tissue growth factor; TGFβ3: transforming growth factor β3; COX2: cyclooxygenase 2; PGE₂: prostaglandin E₂. Reprinted with permission from Talloj, S.K.; Cheng, B.; Weng, J.-P.; Lin, H.-C. (2018). Copyright 2018 ACS Applied Materials & Interfaces, American Chemical Society [121].