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Possible mechanisms underlying the pancreatic cancer chemopreventive effects on C57BL/6J mice received allogenic and orthotopic transplantations of KMPC44 cells. Fx administration prevents tumorigenesis on pancreatic and parietal peritoneum tissues through the suppressions of the CCL21/CCR7 axis downstream of Rho A signal, BTLA, TME, EMT, and adhesion. Blue arrows show inhibition or decrease.
